Ipamorelin is a pentapeptide ghrelin mimetic that acts on the GHSR1a receptor, selectively stimulating GH secretion without significantly affecting cortisol, prolactin, or ACTH [4] [7]
Compared to the native hormones, retatrutide shows 2.9-fold less potency at the glucagon receptor (GCCR), 2.5-fold less potency at the GLP-1 receptor, and 8.9-fold greater potency at human GIP receptor [1]
doi:10.1056/nejm199910143411607 Ranke MB, Wit JM
Hepatology, 2006, 43(1): 173-181
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