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GSH biosynthesis is generally performed by two consecutive ATP-consuming reactions catalyzed by -glutamylcysteine synthetase (-GCS, GSHI) and glutathione synthetase (GS, GSHII) from three precursors in microorganisms: l-glutamate, l-cysteine, and glycine [1]

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For instance, miR130a/b, miR-186, and miR-495 can directly bind to the 3'-UTR of ABCB1 mRNA or regulate the expression of other targets (e.g., PTEN, XIAP, and PI3K) [11, 27], leading to ABCB1 mRNA degradation or translational inhibition

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This can cause a gradual loss of vision and result in blind spots