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For patients with persistent vomiting, targeted thiamine supplementation (50-100 mg daily) may be appropriate under medical supervision rather than high-dose B-complex formulations
Together, they discuss "Semaglutide and Taste in Women With Obesity and Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Study," published in the January 2026 issue of JCEM
In the phase 2 trial, a total of 338 adults aged 18-75 years with a body mass index (BMI) of 27 kg/m2 or 30 kg/m2 and 1 weight related condition (type 2 diabetes excluded) were randomly assigned in a 2:1:1:1:1:2:2 ratio to receive subcutaneous retatrutide 1 mg, 4 mg, 8 mg, or 12 mg or placebo once weekly for 48 weeks
For the trial product estimand, continuous endpoint analyses were conducted using a mixed model for repeated measures with randomized treatment as a factor and baseline endpoint value as a covariate
The 20 mg retatrutide vial is often preferred because it allows higher concentration reconstitution and fewer vial changes
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