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The first successful Achieve-1 study was done to evaluate the safety and efficacy of the drug in treating patients with type 2 diabetes

Standard laboratory handling involves lyophilized 20 C storage, reconstitution in sterile or bacteriostatic water, and aliquoting to limit freeze-thaw cycles

PubMed PMID: 30727890

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The peptide's unique mechanism of action involves modulation of the nitric oxide system, upregulation of critical growth factors (VEGF, EGF, FGF), activation of the FAK-paxillin pathway, and interaction with GABAergic neurotransmission

Second, the FDA has identified instances of compounded semaglutide products that do not contain the correct amount of active ingredient, contain impurities, or are not sterile when they should be