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Megaloblastic anemia Diminished activity of methionine synthase in vitamin B 12 deficiency inhibits the regeneration of tetrahydrofolate (THF) and traps folate in a form that is not usable by the body ( Figure 3 ), resulting in symptoms of folate deficiency even in the presence of adequate folate
Did any serious adverse events occur with AOD-9604
Shao K et al
Hattori M et al
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This interesting review is aimed at primary care clinicians but represents a good reference paper for all healthcare professionals utilising B12 supplements and nutritional guidance to resolve B12 deficiency or dietary inadequacy
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