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This multi-receptor activity distinguishes it from existing approved agents such as semaglutide and tirzepatide, and it is this broader pharmacological profile that is thought to contribute to its cardiovascular effects, including an increase in resting heart rate

The Epothilone B and glutathione-epothilone B conjugate had a binding energy 8.07.7 kcal/mol, respectively, for -tubulin, by multiple non-covalent interactions with binding pockets