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It was thought that an oral formulation may improve convenience, acceptance, and adherence with GLP-1RA therapy, and may provide an additional option to help increase glycemic target achievement, particularly in patients who are reluctant to initiate injectable medications (10)
The retrospective nature also prevents investigators from accounting for non-adherence, which may explain the worsening of glycemic control for a small subset of patients in the case series
Quick Answer: Patients on tirzepatide lose an average of 15-21% of their body weight over 72 weeks, with higher doses producing greater weight reduction
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