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In both male and female GHRKO mice, disruption of the GH/IGF-1 axis from birth results in mice that are remarkably long lived, but temporal disruption of this pathway in young adults (aGHRKO mice) improves lifespan only in females 17 , an observation which is consistent with the beneficial effects of targeting IGF-1R signaling post-development on female healthspan and aging in this study

This tool reports what trials studied and models trajectories at studied doses

The SURMOUNT-1 trial showed mean weight reductions of approximately 15.0% (5 mg dose), 19.5% (10 mg dose), and 20.9% (15 mg dose) at 72 weeks

Garvey WT, Blher M, Osorto Contreras CK, et al

doi:10.1007/s40264-023-01392-3 125

It takes about 5 to 7 weeks for the medication to be fully eliminated and for your bodys natural appetite regulation to return