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However, the role of FXR in improving metabolic dysfunction is contentious, as intestine-specific FXR agonism improves the metabolic profiles of mice 274,275 and increases the expression of TGR5 276 , which mediates bile acid-induced GLP-1 secretion from EECs 277

doi: 10.1210/jcem-41-2-260 120 ChangAMJakobsenGSturisJSmithMJBloemCJAnBet al

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Meyer M, Lara A, Hunt H, Belanoff J, de Kloet ER, Gonzalez Deniselle MC, De Nicola AF (2018) The selective glucocorticoid receptor modulator Cort 113176 reduces neurodegeneration and neuroinflammation in Wobbler mice spinal cord

Glutathione metabolism and its selective modification

Before cellular enzymes can even reach a site of DNA damage, glutathione acts as a rapid, first-line chemical repair agent