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Discovery and design of exosite inhibitors

Gladyshev VN, Stadtman TC, Hatfield DL, Jeang KT

Iron has been thought of to increase free-radical damage in the body and has been linked to an increased risk of cancer and aging, says a study published in the Journal of the National Cancer Institute

Our study describes a novel action of GLP-1 signalling in -cells, which stimulates metabolic/bioenergetic reprograming resulting in a high glycolytic/high ATP generating phenotype, as detailed in (Fig

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Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses