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Oral semaglutide has the longest half-life (165185 h) of the long-acting GLP-1RAs
Fatigue can occur both as a direct side effect and indirectly through several mechanisms related to how these medications work
Bottom line: 500mg is an effective dose for most people, but its "strength" depends entirely on whether it survives digestion and reaches your cells
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"This study investigated important outcomes (hospitalisations) that are very relevant from a clinical and public health standpoint - another important strength of the study." However, more studies and trials are needed to show that these drugs are actually driving change in addictive behaviours.
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