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For instance, chemical synthesis is used for vitamin b1 and b6, while as, fermentation method is employed to get vitamin b12

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However, it also turns out to be true that, under normal conditions, dietary intake of glutathione does not allow its direct use: since it is a tripeptide, enzymes in the gastric juices would break it down into its constituent amino acids, forcing our body to consume energy to synthesize it from scratch

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References Asplund, Rich