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The 12mg weekly arm produced a 24.2% mean body weight reduction over 48 weeks, with 26% of participants achieving at least 30% total body weight loss a threshold previously unattained by any pharmacological intervention in a clinical trial setting

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Retatrutide and Cardiac Rhythm Safety Dose-Dependent Heart Rate Increase With Low Incidence of Clinically Significant Arrhythmias in Phase 2 Obesity Trials Background Retatrutide (LY3437943) is a novel triple agonist targeting GIP, GLP-1, and glucagon receptors, developed for the treatment of obesity and cardiometabolic disease

4-Hydroxynonenal 4-Hydroxynonenal (4HNE) is a lipoperoxidation-derived aldehyde that can damage proteins and DNA through the generation of covalent adducts and is implicated in the control of cell signaling 13,14

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