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362 In an experimental study in which osteoclast formation and bone resorption were induced in mice through lipopolysaccharide (LPS) administration, researchers discovered that simultaneous treatment with exendin-4 resulted in a significant decrease in the number of osteoclasts, the proportion of bone resorption pits, and the levels of the bone resorption marker CTX compared to injection with LPS alone
When two substances with similar physiological effects are taken concurrently, their combined impact can be greater than either taken alone
Of those, just one study was done on humans, with only 12 patients
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Yes, and for the right patient this combination makes clinical sense
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