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Razzaki TS, Weiner A, Shukla AP Therapeutics and Clinical Risk Management 2022, 18:955-964 Published Date: 28 September 2022 Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview Telci Caklili O, Cesur M, Mikhailidis DP, Rizzo M Diabetes, Metabolic Syndrome and Obesity 2023, 16:1767-1774 Published Date: 14 June 2023 The Effect of Tirzepatide on Weight, Lipid Metabolism and Blood Pressure in Overweight/Obese Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Lv X, Wang H, Chen C, Zhao Y, Li K, Wang Y, Wang L, Fu S, Liu J Diabetes, Metabolic Syndrome and Obesity 2024, 17:701-714 Published Date: 12 February 2024 Analysis Using Various Models on the Effect of Metabolic Surgery on Cardiovascular Disease Risk in the Chinese Population with Obesity Wang Z, Xu G, Chen G, Amin B, Wang L, Li Z, Wang J, Chen W, Yu C, Tian C, Wuyun Q, Sang Q, Shang M, Lian D, Zhang N Diabetes, Metabolic Syndrome and Obesity 2024, 17:2457-2468 Published Date: 17 June 2024 Real-World Effectiveness and Safety of Tirzepatide, Semaglutide, and Liraglutide in Adults with Overweight or Obesity without Diabetes: A Comparative Study Cetiner S Diabetes, Metabolic Syndrome and Obesity 2026, 19:594898 Published Date: 31 March 2026

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In 2013, lab tests revealed that an antioxidantalpha-lipoic acidhelped to protect retinal ganglion cells, which are essential for vision and damaged by glaucoma, from oxidative stress

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Safe discontinuation of tirzepatide requires medical oversight and individualized planning, even though formal tapering is not pharmacologically necessary

The DAC moiety is a maleimidoproprionic-acid linker positioned at the C-terminus of the modified GHRH(1-29) parent peptide