Notably, the metabolic benefits of dual GLP-1R/GcgR agonists have also been documented in obese non-human primates, where chronic administration of a lower dose of a GLP-1R/GcgR co-agonist vs a GLP-1R mono-agonist reduced body weight and improved glucose tolerance to a greater degree [77]
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Our recent SNO-proteome analysis of the cortices of Shank3 InsG3680 (+/+) mutant mice showed that several mitochondrial processes, including the ATP metabolic process, transmembrane electron transport, and the cellular response to oxidative stress, were SNO-enriched [64]