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CagriSema drove an average 13.7% weight loss versus 3.4% for placebo, rising to 15.7% with full adherence

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While consensus does not exist regarding the exact synergistic mechanisms by which dual-agonists work, the addition of GIP agonism is posited to improve the HbA1c control and weight loss offered by GLP-1 agonists alone by enhancing insulin secretion, decreasing energy consumption, and stimulating satiety in the hypothalamus

Some platforms use brief health questionnaires reviewed asynchronously by a provider, with the entire process taking minutes