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Wang P, Pan R, Weaver J, Jia MJ, Yang X, Yang TH, et al
In a transected Achilles tendon model in rats, the Sikiric group reported dose-dependent improvement in functional recovery, biomechanical strength, and histological healing markers compared with saline-treated controls [Sikiric et al., Inflammopharmacology, 2018]
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PMID 17183362
Another study done with mice by Forst and colleagues, showed that binding of GLP-1 to the GLP-1 receptor in the myocardium leads to an increase in production of cAMP and activation of protein kinase A, which yields an increase in glucose uptake and the inotropic effects of the heart
The dosing schedules follow the same general principle used across all GLP-1 receptor agonists: start low, escalate gradually, reach a maintenance dose
