Further, she explains that excessive gas is hard to pass through the intestines compared to normal food, and as the intestines try pushing the gas and other foods, it may result in cramping
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63 In addition to their benefits on quality of life in HFpEF, further randomised trials are needed to effectively assess the effects of GLP-1 RA on harder clinical outcomes
Importantly, Dihexa simultaneously increases expression of anti-inflammatory interleukin-10 (IL-10), suggesting the peptide actively shifts the neuroinflammatory balance toward resolution rather than simply suppressing inflammation
Phase 3 trials are ongoing, and without completed large-scale safety and efficacy data, the compound cannot be considered ready for routine clinical use
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