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The interaction of substances can cause side effects such as severe nausea, hypoglycemia, and gastrointestinal distress
If your intake already averages 425-550mg/day, tacking on a supplement may offer little added benefit.70 Individuals with kidney or metabolic disease Elevated TMAO from excess choline is most concerning in people with reduced kidney function or metabolic disorders, where clearance is impaired.69 In these groups, some choline supplements may amplify cardiovascular risk markers
Limitations of this study include its descriptive, observational design, with no statistical comparisons of outcomes within or between treatment cohorts
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However, there is a general consensus among healthcare providers on the type of diet that works best
