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New concepts have recently been included in routine clinical practice and have changed the algorithm of DM2 pharmacological therapy
Managing Initial Side Effects Common side effects during the first few weeks include nausea (the most common), decreased appetite, constipation or diarrhea, stomach discomfort, and fatigue
Lower doses took a bit longer to show clear separation from placebo
Lancet (2019) 394:12130
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However, during starvation, the body also has low levels of sugar and insulin
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