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In the present study, the serum or gastric pro-inflammatory cytokines TNF- and IL-1 as well as the mRNA expression of NF-B were reduced by NPW treatment in the rat gastric tissue, indicating the anti-inflammatory action of NPW against acetic acid-induced gastric injury also occurs through the suppression of NF-B pathway

An essential element of the NLRP1 inflammasome that activates IL-1 is the protein pyrin domain-containing protein 1 [57, 58]

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Acknowledgements PSA is supported by the American College of Medical Genetics Foundation/Genzyme 2014-2015 Fellowship in Biochemical Genetics

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