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Each panel shows a construct (P1 - P15, using the same notation as in the main text) as an array whose entries reflect the prevalence of each amino acid at specific position in the training set, according to the legend on the right side

9,12 Additionally, GLP-1RAs activate nitric oxide (NO) synthase expressed in Schlemms canal and the trabecular meshwork, increasing NO production to reduce trabecular meshwork contraction, improving aqueous outflow

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This decline contributes to fatigue, brain fog, slower metabolism, and aging at the cellular level

19 To minimize risk of APOs, women planning pregnancy with CKM syndrome should undergo preconception counseling 20-22 and optimize CKM risk factors before pregnancy, with lifestyle modification and medication when appropriate

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