In general, animals are well-adapted to mobilize metabolic responses and body constituents to survive periods of food scarcity 100
Patients with certain FTO and MC4R variants, for example, often show enhanced appetite suppression and weight loss when using dual GLP-1/GIP receptor agonists like tirzepatide, potentially allowing metformin reduction or discontinuation more rapidly
Until then the honest summary is: moderate average benefit on insulin need, time in range and weight, a real ketone signal, and a paediatric evidence hole
Strain is the signal here, not birthday
Common CVS Caremark Denial Reasons for Wegovy "Does not meet criteria" BMI or comorbidity requirements not documented "Step therapy not completed" Some plans require trying lifestyle changes first "Insufficient documentation" Missing weight history or comorbidity records "Employer plan exclusion" Some employers exclude weight loss medications entirely What to Do: Get the Denial in Writing Request a written denial letter with the specific reason for denial
Fat women get fewer callbacks