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Drug Metab Dispos 33 , 649656, doi: dmd.104.002964 [pii]10.1124/dmd.104.002964 (2005)

This is a black box warning for the entire GLP-1 class based on thyroid C-cell tumor findings in rodent studies

If you have a history of skin conditions or are concerned about changes in your pigmentation, it is always a wise step to consult with a healthcare professional or a dermatologist

Peretz C, Segev H, Rozani V, Gurevich T, El-Ad B, Tsamir J, et al

Drugs Dermatol

Causes and considerations: Direct taste sensation from the copper-containing complex Post-nasal drip from nasal formulations Transient effect often mitigated with delivery technique adjustments The metallic taste is not typically a clinically meaningful adverse effect, but it can be bothersome enough that patients discontinue therapy