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To further test the role of GCL in modulating glutathione and glutamate, we utilized sulforaphane, which increases GCL expression through activation of the Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) pathway (19)

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However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2

These changes are generally reversible and do not indicate permanent fertility impairment

Liver disorders: Up to 90% of obese individuals have non-alcoholic fatty liver disease (NAFLD), a precursor to the potentially life-threatening NASH