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References 1 HolstJJ

Glinides are insulin secretagogues that lack the sulfamide group of the sulfonylureas and differ from sulfonylureas in receptor affinity, binding sites, duration of action and mechanism of absorption and elimination ( According to data from several meta-analyses, an overall increased cancer risk was reported in patient using sulfonylureas compared with those treated with metformin or other diabetes medications (Wu et al., 2015

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[42] Agarwal A, Sengupta P, Durairajanayagam D

This process not only maintains gut barrier integrity but also creates metabolic byproducts that stimulate L-cell activity