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The downregulation of the two subunits of system Xc-, SLC3A2 and SLC7A11, impairs the tumor cells' cystine uptake, promoting LPO and ferroptosis in tumor cells
To prepare such formulations the pharmaceutical industry predominantly employs traditional technologies, often high shear blenders, with little advancement in the manufacturing process over the last 30 years
cruzi can potentially infect 1000's of vertebrate species, and at least 40 invertebrate species (Teixeira et al., 2009)
(August 2016)
Generic competition for peptide drugs is more limited than for small molecule medications due to the complexity of peptide manufacturing and regulatory approval processes
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