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Yang CS, Chiu SC, Liu PY, Wu SN, Lai MC, Huang CW

Subsequently, lactate accumulation causes a decrease in intracellular pH, negatively impacting cellular functionality and potentially inducing cell death [41]

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Collectively, to better understand the therapeutic potential of NADPH metabolism, more preclinical and clinical studies should be implemented to address these difficulties, and combined approaches with immunotherapy and/or chemotherapeutics should be pursued as the best strategies because of their synergistic effects

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