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GLP-1-RAs and metabolic adaptation Metabolic adaptation is the difference between the observed resting energy expenditure and the estimated resting energy expenditure post-weight loss [51]

[1] [7] Other frequent side effects include vomiting, diarrhoea, constipation, and abdominal discomfort

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Eating below 1,200 calories (women) or 1,500 calories (men) for extended periods risks metabolic adaptation, nutrient deficiency, and accelerated muscle loss