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A 2017 meta-analysis found no significant increase in pancreatitis or pancreatic cancer risks (odds ratios 0.93 and 0.94, respectively)
Both AOD 9604 and MOTS-C are peptides, which means they are short chains of amino acids
Onset and offset of therapeutic effects are directly related to the drug's half-life
Thus, trained immunity is a double-edged sword, its net effect depends on whether it enhances or aggravates the tissue response
Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM
30 EMPIRE randomized 116 ST-segment elevation myocardial infarction patients to exenatide or placebo in parallel groups and showed that at 6 months (n=58), exenatide reduced E/e with improved strain parameters, measured by conventional and speckle tracking echocardiography (NCT01580514)
