doi.org/10.1038/s41598-020-73429-x
The question isn't just "does Ipamorelin cause water retention?" but rather, "does the product I'm using contain only Ipamorelin?" With a high-quality compound, the risk of water retention is exceptionally low, allowing the true, targeted effects of the peptide to be observed
Choosing the Right Supplement: Collagen, Glutathione, or Both
Cutting back to 2 to 3 applications per week, pausing other actives, and supporting the barrier with a gentle moisturiser usually resolves the reaction within a month
2017;66:684 Pascual G, Domnguez D, Elosa-Bayes M, Beckedorff F, Laudanna C, Bigas C, et al
Methods in Enzymology