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2 There is also a much-discussed link to the Wnt/-catenin pathway, which is a genuine master regulator of the hair cycle: active -catenin signaling in the dermal papilla drives follicles into anagen and enhances their hair-inducing capacity, while reduced signaling is associated with regression and miniaturization

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Transplantation of 3MA-treated skin organoids onto the back of the nude mice led to significantly fewer hair regeneration compared to the control (Fig