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DAM release superoxide radicals (i.e., ROS), nitric oxides, and pro-inflammatory cytokines and factors (IL-1, TNF-, C1q), which induce neurotoxic C3 + reactive astrocytes (Liddelow et al., 2017)

Use of other drugs, such as vigabatrin, netilmicin and flucloxacillin, was also reported as an alternative cause of pyroglutamic acidosis

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others require injection

Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential

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