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In the early weeks and at lower doses, semaglutide may not fully suppress appetite

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Combination therapy is most appropriate for patients with obesity plus type 2 diabetes, prediabetes, or significant insulin resistance, where controlling blood sugar and weight are equally important treatment goals

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(PubMed) Reinhart KM, Coleman CI, Teevan C, Vachhani P, White CM

Each one is used for different purposes and comes in different forms and doses