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Springer Link , doi:10.1007/s00394-019-01919-4

ACTL6A regulates GCLC in transcriptional level via NRF2 The synthesis of -GC is catalyzed by GCL, which is the rate-limiting enzyme in the GSH biosynthesis pathway

MOTS-C does it directly, by suppressing TNF-alpha, IL-6, and IL-1 beta at the cellular level

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