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For people not losing weight on tirzepatide , or those who have plateaued on GLP-1/GIP dual agonism, survodutide represents a mechanistically different approach that could work where tirzepatide has stopped working
The combination is well-tolerated because cagrilintide targets amylin receptors while semaglutide activates GLP-1 receptors, meaning the mechanisms dont overlap and produce additive effects rather than redundant signalling
The source hierarchy that goes from meta-analyses at the top to "guy on Twitter" at the bottom
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