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9 Importantly, the key enzyme of GSH synthesis, gamma-glutamyl-cysteinyl-synthetase, is already active by the 2nd trimester of pregnancy, suggesting enzymatic immaturity is unlikely to be a primary limiting factor

Xenografted tumors from siHNF4 HepG2 cells maintained partial HNF4 knockdown during our experiment timeframe (about 5 weeks, Supplementary Fig

Hamada A, Tanaka Y, Ishikawa T, Maruta T (2023) Chloroplast dehydroascorbate reductase and glutathione cooperatively determine the capacity for ascorbate accumulation under photooxidative stress conditions

The presence of Nrf2 and its inhibitor Keap1 in plasma is associated with damaged vascular endothelial cell-, macrophage-and other cell-associated leakage secondary to the loss of cell membrane integrity due to lipid peroxidation following chronic inflammation and oxidative stress (Kasprzak et al., 2020), and Nrf2 and Keap1 in circulation are markers of severe inflammation and oxidative stress (Tu et al., 2019)

Dig Dis Sci 57: 835-841, 2012