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In histamine intolerance, the body cannot break down histamine efficiently, often due to low levels of diamine oxidase (DAO) enzyme or impaired methylation pathways

Consequently, aberrant eating behaviors, such as binge eating and food avoidance, often result from deficits in inhibitory control and other cognitive functions [34]

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But of more concern is really that it can cause receptor desensitization, maybe even turn off the whole receptor pathway

A mutant impaired in the major high-affinity sulfate transporter SULTR1;2 responsible for uptake in Arabidopsis roots was reported earlier to contain decreased amounts of glutathione 83 but our data indicate that sultr1;2 seedlings exposed to AITC have a WT-like response