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In another study, female Wistar rats treated with pure tamoxifen was compared to the control group on 7,12-dimethylbenz(a)anthracene (DMBA) and to a group treated with tamoxifen loaded poly(d,l-lactic acid) (PLA) nanoparticles (NPs), the tumor size was significantly reduced in groups treated with NPs as compared to pure Tmx and untreated group [106]
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Animal studies show mostly mild local irritation at injection sites
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