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A la fecha de esta publicacin, no existen ensayos clnicos de fase III registrados en ClinicalTrials.gov que demuestren que los parches GLP-1 reduzcan la hemoglobina A1c, promuevan prdida de peso sostenida, o mejoren resultados cardiovasculares

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These regions are believed to be involved in many of the non-enzymatic functions of DPP-4, interacting with other proteins, such as adenosine deaminase, caveolin-1, streptokinase and plasminogen, and with components of the extracellular matrix (collagen, fibronectin), as well as functioning as binding sites for the chemokine CXCR4 receptor, the T-cell differentiation antigen, CD45, and the sodium-hydrogen exchanger-3, among others ( Table 1 The proline-specific peptidases

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Cellular redox signaling, influenced by fluctuations in ROS, RNS, and antioxidant systems, governs vital functions like cell growth, programmed death, and immune responses [112]

et al., 2023) , Oscillibacter and Ruminococcus (Jiang et al., 2023), and Lachno Clostridium (Chen et al., 2023)