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These changes create NDP--MSH (Nle4, D-Phe7--MSH), which is approximately 100-1000 times more potent than native -MSH at the MC1R receptor and is resistant to enzymatic degradation

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Xerostomia commonly known as dry mouth has many causes besides vitamin deficiencies, including dehydration, alcohol use, smoking, anxiety, certain medications, or underlying conditions such as diabetes and Sjogren's syndrome (a chronic autoimmune disorder)