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doi: 10.1016/j.clinme.2024.100030 [PubMed] 39407841 Scafetta T, Kovacs O, Milani GP, Bronz G, Lava SAG, Betti C, Vanoni F, Bianchetti MG, Far PB, Camozzi P
COMT is involved in converting 2-hydroxyestradiol (an antiestrogen) to 2-methoxyestradiol (proestrogen), creating a hyper-estrogenic milieu due to the decrease in antiestrogen and an increase in proestrogen
Neurology , 68 (5), 343349
It was characterised as the first selective compound of its class, meaning it stimulates growth hormone release with comparatively little effect on cortisol and prolactin (Raun et al., European Journal of Endocrinology , 1998)
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