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Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

Artif Cells Nanomed Biotechnol (2019) 47(1):176671

Get the details in the Concerns and Cautions section of our Probiotics Supplements Review

The field requires urgent Phase I/II human trials before any clinical recommendations can be made

While that initial boost is great, the real goal is to maintain your B12 levels over time so you can enjoy sustained energy and focus without the ups and downs