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4.1 Trial evidence: recording and limitations of taste-related outcomes in RCTs and PROs In randomised controlled trials (RCTs), primary outcomes are typically focused on body weight and metabolic endpoints, whereas eating-experience-related outcomes are rarely included as prespecified measures and are more often captured only sporadically as adverse events (AEs) (69)
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NRF2 knockdown was found to suppress the expression of fatty acid oxidation genes ACOX1, ACOX2, CPT1, and CPT2 [77], and NRF2 activation in the mouse lung induces the expression of fatty acid oxidation genes and lipases
Table 3 describes the most frequently reported suspected ADRs for both potential counterfeit and non-counterfeit semaglutide
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Coty divested its stake to Skims in March 2025
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