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If the cell cannot recycle GSSG back into GSH fast enough using an enzyme called glutathione reductase, the cell enters a state of toxic oxidative stress, leading to mitochondrial damage and, eventually, programmed cell death (apoptosis)

In a medical setting, nebulized (inhaled) glutathione is sometimes used for certain lung conditions

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Glutathione supplements typically show noticeable effects after 412 weeks of consistent daily use, depending on individual response