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Figure 2 Regulation of Acetyl-CoA/CoA Ratio Under physiological conditions, carnitine can buffer excess acetyl-CoA in the mitochondria via the formation of acetyl-carnitine ( Inter-organellar Acyl Transfer Long-chain fatty acids (LCFA) and branched chain fatty acids are oxidized in peroxisomes

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For humans, self-production of B12 through the intestinal bacteria is theoretically possible, but rarely achieved for health reasons, which is why humans today depend on a dietary intake of B12 in almost all cases