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This depletion leaves the mitochondriathe powerhouses of our cellsvulnerable to damage, effectively starving the brain and muscles of the energy they need to function

The inability to concentrate the urine results in hyponatremia, hypochloremia, hypokalemia, metabolic alkalosis, and low blood pressure

For nasal delivery specifically, TB-500 molecular size presents considerations

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(PubMed) Hankey GJ

Based on these data A-GSH targeting may increase the initial binding step of nanocarrier cell entry that in turn would lead to increased endocytosis