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The American Gastroenterological Association's 2022 clinical practice update states: "GLP-1 receptor agonists should be avoided in patients with a history of pancreatitis until further safety data are available." [5] Mochi Health's intake form may capture a pancreatitis history, but there is no published information about whether the platform routes those patients to specialist review or simply declines to prescribe

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This suggests that the joint is exposed to circulating GLP-1, but only to a limited extent under physiological conditions

Source, dose, formulation, quality, prescribing oversight, and regulatory status matter