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Semaglutide withdrawal is not dangerous, but the return of appetite and potential weight regain can be psychologically challenging

There have also been reports of gastrointestinal side effects ranging from mild to moderate and transient disturbances, as well as injection-site reactions and allergic responses

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Logistic regression analysis confirmed that neither the timing of the last dose, medication dose, nor therapy duration was meaningfully related to gastric content or volume, reinforcing the idea that withholding GLP-1 therapy alone is insufficient to reduce aspiration risk if fasting remains inadequate